Human CD209 Protein; His Tag

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£195.00

SKU:: PME101437
Zusätzliche Namen:: CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; hDC-SIGN
Molekulargewicht:: The protein has a predicted molecular mass of 40.3 kDa after removal of the signal peptide. The apparent molecular mass of His-CD209 is approximately 35-55 kDa due to glycosylation.
Reinheit:: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Lagerbedingungen:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Hersteller:: DIMA Biotechnology Ltd
Formulierung:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: CD209
6×His tag CD209(Gln59-Ala404):: 6×His tag CD209(Gln59-Ala404)
Weitere Details:: This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health; including leprosy and tuberculosis mycobacteria; the Ebola; hepatitis C; HIV-1 and Dengue viruses; and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain; a flexible tandem-repeat neck domain; a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene; CLEC4M (Gene ID: 10332); also known as L-SIGN. The two genes differ in viral recognition and expression patterns; with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection; while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease; including rs4804803; which is associated with SARS severity. [provided by RefSeq; May 2020]

Versandbedingungen:: Ambient