PME101417
Human LEP Protein; hFc Tag
Größe
£174.00
- SKU:
- PME101417
- Zusätzliche Namen:
- OB; OBS; LEPD
- Molekulargewicht:
- The protein has a predicted molecular mass of 42.2 kDa after removal of the signal peptide. The apparent molecular mass of LEP-hFc is approximately 35-55 kDa due to glycosylation.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing).Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
- Target:
- LEP
- LEP(Val22-Cys167) hFc(Glu99-Ala330):
- LEP(Val22-Cys167) hFc(Glu99-Ala330)
- Weitere Details:
- This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain; which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions; and is involved in the regulation of immune and inflammatory responses; hematopoiesis; angiogenesis; reproduction; bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq; Aug 2017]
- Versandbedingungen:
- Ambient