PME101347
Human C5 Protein; His Tag
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£178.00
- SKU:
- PME101347
- Zusätzliche Namen:
- C5D;C5a;C5b;ECLZB;CPAMD4
- Molekulargewicht:
- The protein has a predicted molecular mass of 187.9 kDa after removal of the signal peptide.
- Reinheit:
- The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- C5
- C5(Gln19-Cys1676) 10×His tag:
- C5(Gln19-Cys1676) 10×His tag
- Weitere Details:
- This gene encodes a component of the complement system; a part of the innate immune system that plays an important role in inflammation; host homeostasis; and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products; including the C5 alpha chain; C5 beta chain; C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains; which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin; which possesses potent spasmogenic and chemotactic activity; and the C5b macromolecular cleavage product; a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency; a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq; Nov 2015]
- Versandbedingungen:
- Ambient