PME101261
Human MRGPRX2 Protein; hFc Tag
Größe
£169.00
- SKU:
- PME101261
- Zusätzliche Namen:
- MGRG3;MRGX2
- Molekulargewicht:
- The protein has a predicted molecular mass of 29.6 kDa after removal of the signal peptide. The apparent molecular mass of MRGPRX2-hFc is approximately 35-55 kDa due to glycosylation.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- MRGPRX2
- MRGPRX2(Met1-Pro33) hFc(Glu99-Ala330):
- MRGPRX2(Met1-Pro33) hFc(Glu99-Ala330)
- Weitere Details:
- Mast cell-specific receptor for basic secretagogues; i.e. cationic amphiphilic drugs; as well as endo- or exogenous peptides; consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ); such as non-steroidal neuromuscular blocking drugs (NMBDs); including tubocurarine and atracurium. In response to these compounds; mediates pseudo-allergic reactions characterized by histamine release; inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands; including peptides and alkaloids; such as cortistatin-14; proadrenomedullin N-terminal peptides PAMP-12 and; at lower extent; PAMP-20; antibacterial protein LL-37; PMX-53 peptide; beta-defensins; and complanadine A.[UniProtKB/Swiss-Prot Function]
- Versandbedingungen:
- Ambient