Human Selenop Protein; Flag Tag

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£178.00

SKU:: PME101215
Zusätzliche Namen:: SELP;SeP;SEPP;SEPP1
Molekulargewicht:: The protein has a predicted molecular mass of 42.5 kDa after removal of the signal peptide.
Reinheit:: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Lagerbedingungen:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Hersteller:: DIMA Biotechnology Ltd
Formulierung:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: Selenop
Selenop(Met1-Asn381) 3×Flag tag:: Selenop(Met1-Asn381) 3×Flag tag
Weitere Details:: This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human); and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant; and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction; suggesting its importance in normal brain function. Sec is encoded by the UGA codon; which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure; designated the Sec insertion sequence (SECIS) element; that is necessary for the recognition of UGA as a Sec codon; rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites; one located in between the two SECIS elements; results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene.

Versandbedingungen:: Ambient