PME100982
Human MRP1 Protein; hFc Tag
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£171.00
- SKU:
- PME100982
- Zusätzliche Namen:
- HDMX;MDMX;MRP1
- Molekulargewicht:
- The protein has a predicted molecular mass of 56.7 kDa after removal of the signal peptide.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- MRP1
- MRP1(Met1-Phe33) hFc(Glu99-Ala330):
- MRP1(Met1-Phe33) hFc(Glu99-Ala330)
- Weitere Details:
- This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus; and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity; and have been shown to be overexpressed in a variety of human cancers. However; unlike MDM2 which degrades p53; this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain; and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53; while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq; Feb 2011]
- Versandbedingungen:
- Ambient