PME100884
Human IL17A Protein; hFc Tag
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£190.00
- SKU:
- PME100884
- Zusätzliche Namen:
- CTLA-8;CTLA8;IL-17;IL-17A;IL17;ILA17
- Molekulargewicht:
- The protein has a predicted molecular mass of 41.3 kDa after removal of the signal peptide.The apparent molecular mass of IL17A-hFc is approximately 35-55 kDa due to glycosylation.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- IL17A
- IL17A(Gly24-Ala155) hFc(Glu99-Ala330):
- IL17A(Gly24-Ala155) hFc(Glu99-Ala330)
- Weitere Details:
- This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules; chemokines; antimicrobial peptides; and remodeling proteins. The encoded protein elicits crucial impacts on host defense; cell trafficking; immune modulation; and tissue repair; with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2); as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases; inflammatory and autoimmune disorders; and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis; psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent; a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq; Sep 2020]
- Versandbedingungen:
- Ambient