PME100882
Human IL15 Protein; hFc Tag
Größe
£171.00
- SKU:
- PME100882
- Zusätzliche Namen:
- IL-15;Interleukin 15;MGC9721
- Molekulargewicht:
- The protein has a predicted molecular mass of 38.9 kDa after removal of the signal peptide. The apparent molecular mass of IL15-hFc is approximately 35-55kDa due to glycosylation.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- IL15
- IL15(Asn49-Ser162) hFc(Glu99-Ala330):
- IL15(Asn49-Ser162) hFc(Glu99-Ala330)
- Weitere Details:
- The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits; and may compete for the same receptor; and thus negatively regulate each other's activity. The number of CD8 memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases; as well as the phosphorylation and activation of transcription activators STAT3; STAT5; and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L); possibly through the transcription activation activity of STAT6; and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq; Feb 2011]
- Versandbedingungen:
- Ambient