PME100864
Human CRLF2 Protein; hFc Tag
Größe
£171.00
- SKU:
- PME100864
- Zusätzliche Namen:
- CRL2;CRLF2Y;TSLPR
- Molekulargewicht:
- The protein has a predicted molecular mass of 48.51 kDa after removal of the signal peptide.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- CRLF2
- CRLF2(Gln23-Lys231) hFc(Glu99-Ala330):
- CRLF2(Gln23-Lys231) hFc(Glu99-Ala330)
- Weitere Details:
- This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R); the encoded protein and TSLP activate STAT3; STAT5; and JAK2 pathways; which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14; or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.
- Versandbedingungen:
- Ambient