PME100588
Human c-MPL Protein; hFc Tag
Größe
£181.00
- SKU:
- PME100588
- Zusätzliche Namen:
- C-MPL;CD110;MPLV;THCYT2;THPOR;TPOR
- Molekulargewicht:
- The protein has a predicted molecular mass of 78.5 kDa after removal of the signal peptide.The apparent molecular mass of c-MPL-hFc is approximately 100-130 kDa due to glycosylation.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- c-MPL
- c-MPL(Gln26-Ala490) hFc(Glu99-Ala330):
- c-MPL(Gln26-Ala490) hFc(Glu99-Ala330)
- Weitere Details:
- In 1990 an oncogene; v-mpl; was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue; named; c-mpl; was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl; thrombopoietin; was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene; CD110; is a 635 amino acid transmembrane domain; with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic; emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases; as well as the STAT family; the MAPK family; the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq; Jul 2008]
- Versandbedingungen:
- Ambient