PME100525
Mouse BTLA Protein; mFc Tag
Größe
£177.00
- SKU:
- PME100525
- Zusätzliche Namen:
- BTLA;D272
- Molekulargewicht:
- The protein has a predicted molecular mass of 42.7 kDa after removal of the signal peptide.The apparent molecular mass of Mouse-BTLA-mFc is approximately 55-70 kDa due to glycosylation.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- BTLA
- Mouse BTLA(Glu30-Pro176) mFc(Pro99-Lys330):
- Mouse BTLA(Glu30-Pro176) mFc(Pro99-Lys330)
- Weitere Details:
- Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776; PubMed:14652006). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions; appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions; can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).
- Versandbedingungen:
- Ambient