PME100130
Human ADORA2A Protein; hFc Tag
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£171.00
- SKU:
- PME100130
- Zusätzliche Namen:
- A2aR;ADORA2;RDC8
- Molekulargewicht:
- The protein has a predicted molecular mass of 31.7 kDa after removal of the signal peptide.The apparent molecular mass of ADORA2A-hFc is approximately 35-55 kDa due to glycosylation.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- ADORA2A
- ADORA2A(Met1-Ser7) (Ser67-His75) (Asn144-Pro173) (Cys259-Pro266) hFc(Glu99-Ala330):
- ADORA2A(Met1-Ser7) (Ser67-His75) (Asn144-Pro173) (Cys259-Pro266) hFc(Glu99-Ala330)
- Weitere Details:
- This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily; which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein; an adenosine receptor of A2A subtype; uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions; such as cardiac rhythm and circulation; cerebral and renal blood flow; immune function; pain regulation; and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified; but it is thought to be non-coding. [provided by RefSeq; Jun 2013]
- Versandbedingungen:
- Ambient