Human GITR Protein; hFc-His tag

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£195.00

SKU:: PME100018
Zusätzliche Namen:: AITR;GITR;TNFRSF18;CD357
Molekulargewicht:: The protein has a predicted molecular mass of 51-52 kDa after removal of the signal peptide.
Reinheit:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Lagerbedingungen:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Hersteller:: DIMA Biotechnology Ltd
Formulierung:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: GITR
GITR(Gln26-Pro162) hFc(Glu99-Ala330) 6×His:: GITR(Gln26-Pro162) hFc(Glu99-Ala330) 6×His
Weitere Details:: This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation; and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25( )CD4( ) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.