PME100008
Human CD47 Protein; mFc-His Tag
Größe
£181.00
- SKU:
- PME100008
- Zusätzliche Namen:
- CD47;MER6;IAP;OA3
- Molekulargewicht:
- The protein has a predicted molecular mass of 60 kDa after removal of the signal peptide.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- CD47
- CD47(Gln19-Glu141) CD47(Val198-Ala207) CD47(Ser257-Gly268) mFc(Pro99-Lys330) 6×His tag:
- CD47(Gln19-Glu141) CD47(Val198-Ala207) CD47(Ser257-Gly268) mFc(Pro99-Lys330) 6×His tag
- Weitere Details:
- Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3; Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets; and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA; binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion; enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
- Versandbedingungen:
- Ambient