PME-M100122
Mouse GDF15 Protein; hFc Tag
Größe
£181.00
- SKU:
- PME-M100122
- Zusätzliche Namen:
- SBF; MIC-1; NAG-1
- Molekulargewicht:
- The protein has a predicted molecular mass of 38.7 kDa after removal of the signal peptide. The apparent molecular mass of hFc-mGDF15 is approximately 35-55 kDa due to glycosylation.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- GDF15
- hFc(Glu99-Ala330) Mouse GDF15(Ser189-Ala303):
- hFc(Glu99-Ala330) Mouse GDF15(Ser189-Ala303)
- Weitere Details:
- This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types; acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia; inflammation; acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons; and more rapid blood clot formation. [provided by RefSeq; Aug 2016]
- Versandbedingungen:
- Ambient