PME-M100080
Mouse TREM2 Protein; hFc Tag
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£174.00
- SKU:
- PME-M100080
- Zusätzliche Namen:
- TREM-2;Trem2a;Trem2b;Trem2c
- Molekulargewicht:
- The protein has a predicted molecular mass of 42.9 kDa after removal of the signal peptide.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- TREM2
- Mouse TREM2(Leu19-Ser171) hFc(Glu99-Ala330):
- Mouse TREM2(Leu19-Ser171) hFc(Glu99-Ala330)
- Weitere Details:
- The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors; such as kinases and phospholipase C-gamma; to form a receptor signaling complex that activates myeloid cells; including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq; Jan 2013]
- Versandbedingungen:
- Ambient