AT7004-MIGG1
oYo-Link[R] mIgG1 DM4 Antibody Labeling Reagent
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£500.00
- SKU:
- AT7004-MIGG1
- Anwendung:
- FuncS
- Konzentration:
- 337 ug/mL
- Physischer Zustand:
- Dried pellet
- Molekulargewicht:
- 10 kDa
- Lagerbedingungen:
- 2-8[o]C, -70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- AlphaThera
- Buffer:
- PBS
- Weitere Details:
- Research Use Only Application: Antibody conjugation reagent for Targeted cell death; Targeted cell death for cancer cells; High-throughput screening with cell killing assays oYo-Link® DM4 is an Antibody-Drug Conjugation reagent allowing for site-specific labeling of DM4 drug labels to the heavy-chains of compatible antibodies with up to two labels per antibody. oYo-Link® limits the attachment of the DM4 drugs to the heavy chains of the antibody and therefore ensures that the drug label does not interfere with antibody binding. Furthermore, site-specific labeling limits 1-2 DM4 drugs to be attached per antibody, providing precise antibody-drug conjugate ratios. As a synthetic derivative of the microtubule-targeted agent ravtansine, also known as the maytansinoid DM4, the DM4 ADC is an antibody-conjugatable, anti-mitotic agent that overcomes systemic toxicity associated with ravtansine and enhances tumor-specific delivery. The antibody labeling procedure simply requires mixing oYo-Link® DM4 with the desired antibody followed by photocrosslinking with non-damaging black light (365 nm). Photocrosslinking can be carried in most buffers, including those containing amine-containing molecules (e.g. TRIS, glycine) or storage proteins. Catalog # AT7004 Requirements: To label your compatible antibodies with oYo-Link®, you will need a Light Source emitting at 365nm (6-10W). Use your own Compatible Device from our list or purchase AlphaThera's LED Photo-Crosslinking Device. Technical Support: For science questions or questions concerning compatibility email [email protected]
- Versandbedingungen:
- Ambient