1492
Myogenic differentiation 1 Adenovirus (Ad-MyoD)
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£631.00
- SKU:
- 1492
- Zusätzliche Namen:
- Ad-MyoD|Myogenic differentiation 1 Adenovirus
- Konzentration:
- 1E10 PFU/ml
- Lagerbedingungen:
- -70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Vector Biolabs
- Buffer:
- DMEM, 2% BSA, 2.5% Glycerol
- Spezies:
- Virus
- Weitere Details:
- Differentiation of myogenic cells is regulated by multiple positive and negative regulators. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes MyoD, myogenin, Myf-5, Myf-6 (also designated MRF-4 or herculin) and musculin (also designated MyoR). Members of this group of transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, ITF2 and HEB. The E2A gene encodes at lest two different proteins, E12 and E47, as a result of alternative splicing. The myocyte enhancing factor-2 (MEF-2) family of transcription factors includes four splice variants A, B, C and D which encode muscle-specific DNA binding proteins that recognize an A/T rich sequence [CTA (A/T)4 TAG] localized in the control regions of numerous muscle-specific genes. This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis., vectorbiolabs
- Versandbedingungen:
- Dry Ice