1288
PUMA Adenovirus (Ad-PUMA)
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£631.00
- SKU:
- 1288
- Zusätzliche Namen:
- Ad-PUMA|PUMA Adenovirus
- Konzentration:
- 1E10 PFU/ml
- Lagerbedingungen:
- -70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Vector Biolabs
- Buffer:
- DMEM, 2% BSA, 2.5% Glycerol
- Spezies:
- Virus
- Weitere Details:
- PUMA (p53 up-regulated modulator of apoptosis) is a BH3-only protein. Each of the "BH3-only" group of proteins contains an amphipathic Bcl-2 homology (BH) domain. These proteins act as sensors of discrete apoptotic stimuli, antagonizing or activating the function of multidomain Bcl-2 family proteins by interacting with them. This in turn triggers a cascade of downstream events, such as the collapse of mitochondrial membrane potential, release of the apoptogenic mitochondrial proteins cytochrome c and SMAC, and activation of caspases.PUMA plays a vital role in mediating the apoptotic responses to p53. It can be activated by p53 directly through p53-responsive elements in its promoter region. The PUMA protein interacts with Bcl-XL and promotes mitochondrial translocation and multimerization of Bax.This adenovirus expresses human PUMA fused to a HA tag. Reference: Yu J., et al., Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1931-6., vectorbiolabs
- Versandbedingungen:
- Dry Ice