APC Adenovirus (Ad-CBR)

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£631.00

SKU:: 1283
Zusätzliche Namen:: Ad-CBR|APC Adenovirus
Konzentration:: 1E10 PFU/ml
Lagerbedingungen:: -70[o]C Avoid freeze/thaw cycles.
Hersteller:: Vector Biolabs
Buffer:: DMEM, 2% BSA, 2.5% Glycerol
Spezies:: Virus
Weitere Details:: Adenomatous polyposis coli gene (APC) is a tumor suppressor gene located on chromosome 5q2. It is inactivated in most colorectal tumors. APC is a cytoplasmic protein that can bind to and promote the degradation of b-catenin. In most colorectal tumors, APC is inactivated. This increases the interaction between b-catenin and Tcf family of transcription factors, leading to increase transcription of genes such as c-Myc. This adenovirus contains APC mini-me fragment. Shih IM., et al., Cancer Res. 2000 Mar 15;60(6):1671-6., vectorbiolabs