ZRANB1 (Zinc Finger Ran-binding Domain-containing Protein 1, TRAF-binding Domain-containing Protein, hTrabid, Ubiquitin Thioesterase ZRANB1, TRABID, hTrabid)

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£642.00

SKU:: Z0850-50A
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide corresponding to KWLDRYRQIRPCTS from the C-terminal of human ZRANB1. Species Sequence Homology: bovine, canine, mouse, porcine and rat
Format:: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Weitere Details:: Positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. Acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: ELISA (Peptide): 1:4000 Western Blot: 1-3ug/ml,using human brain (cerebellum) lysates. Band at ~80kD. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.