V2780-01

VOPP1, Recombinant, Human, aa82-172, His-Tag (Vesicular, overexpressed in cancer, prosurvival protein 1, ECOP, GASP)

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£576.00

SKU:: V2780-01
Molekulargewicht:: 12
Reinheit:: ~90% (SDS-PAGE)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Format:: Supplied as a liquid in 20mM Tris-HCl buffer, pH 8, 1mM DTT, 0.2M sodium chloride, 30% glycerol.
Weitere Details:: Vesicular, overexpressed in cancer, prosurvival protein 1(VOPP1), also known as Glioblastoma-amplified secreted protein (GASP), has been previously shown to be over-expressed in human glioblastoma multiforme and squamous cell carcinoma. VOPP1 is a key regulator of NF-kappaB signaling, and that high-level, amplification-mediated VOPP1 expression, such as that occurring in tumors with amplified EGFR, could contribute to resistance to apoptosis. Purified by using conventional chromatography techniques. Source: Recombinant coresponding to aa82-172 of human VOPP1, fused to His-tag at N-terminus, expressed in E.coli. AA Sequences: MGSSHHHHHH SSGLVPRGSH MRRRMYPPPL IEEPAFNVSY TRQPPNPGPG AQQPGPPYYT DPGGPGMNPV GNSMAMAFQV PPNSPQGSVA CPPPPAYCNT PPPPYEQVVK AK Molecular Weight: ~12kD (112aa), confirmed by MALDI-TOF Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.