Urea Transporter A1 (Slc14a2. Solute carrier family 14 (urea transporter), member 2, Slc14a2T, Solute carrier family 14 member 2, Urea transporter, kidney, Urea transporter 2, UrT1-C, UrT1-D, Ut2)

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£576.00

SKU:: U2013-10A
Reinheit:: Purified by immunoaffinity chromatography
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to aa911-929 at the C-terminal tail of rat UT-A1.
Format:: Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Weitere Details:: UT-A1 (Urea Transporter A1), encoded by the SLC14A2 gene, is a membrane-bound protein primarily expressed in the kidney, where it plays a critical role in urea reabsorption and osmoregulation. While traditionally studied in renal physiology, emerging interest in systemic metabolic regulation and brain-kidney axis signaling has prompted investigation into UT-A1’s potential roles beyond the kidney. Recent studies suggest that altered urea metabolism and systemic nitrogen imbalance may contribute to neuroinflammatory and neurodegenerative processes. Elevated brain urea levels have been observed in disorders such as Alzheimer’s disease and Huntington’s disease, implicating dysregulated urea handling in neuronal dysfunction. Although UT-A1 expression in the central nervous system remains limited, its systemic influence on urea clearance and osmotic balance may indirectly affect brain homeostasis. Understanding UT-A1’s regulatory mechanisms and its interaction with other solute transporters could provide new insights into metabolic contributions to neurodegeneration. As research into the gut-brain and kidney-brain axes expands, UT-A1 may emerge as a peripheral biomarker or therapeutic target in the broader landscape of neurodegenerative disease research. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence/Immunocytochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000. 1ug/ml detected UT-A1 in 20ug of rat kidney tissue lysate by colorimetric immunoblot analysis using IgG goat x rabbit (HRP) as the secondary antibody. Immunohistochemistry (FFPE): 1:25 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice