U1000-86M
UBE2D1, CT (Ubiquitin-conjugating Enzyme E2-D1, Ubiquitin-protein Ligase D1, Ubiquitin Carrier Protein D1, UbcH5, Ubiquitin-conjugating Enzyme E2-17kD 1, Ubiquitin-conjugating Enzyme E2(17)KB 1, UBC4/5 Homolog, Stimulator of Fe Transport, SFT, SFT, UBC5A, UBCH5, UBCH5A)
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£696.00
- SKU:
- U1000-86M
- Reinheit:
- Purified by ammonium sulfate precipitation
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids aa111-140 in the C-terminal region of human UBE2D1. Species sequence homology: bovine, rat
- Format:
- Supplied as a liquid in PBS, 0.09% sodium azide.
- Weitere Details:
- The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D1 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunohistochemistry: 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice