T5469-92HX

Tim-3 (T Cell Immunoglobulin and Mucin Domain Containing Protein 3, Hepatitis Virus Cellular Receptor 2, CD366)

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£607.00

SKU:: T5469-92HX
Anwendung:: Flow Cytometry
Reinheit:: Purified by affinity chromatography. Endotoxin: ≤0.01EU/ug (LAL)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Mouse
Immunogen:: Human Tim-3 fusion protein
Klon:: 11E365 (F38-2E2)
Format:: Supplied as a liquid in PBS, pH 7.2. No preservative added.
Weitere Details:: CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: ≤0.5ug/10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.