T2550-02B
Tenascin (TN, Tenascin-C, TNC, TN-C, Cytotactin, Glioma-associated Extracellular Matrix Antigen, GMEM, Hexabrachion, HXB, JI, Myotendinous Antigen, Neuronectin)
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£927.00
- SKU:
- T2550-02B
- Reinheit:
- Purified
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Tenascin polypeptides isolated from spent culture supernatant of human fibroblasts isolated by affinity chromatography.
- Klon:
- DB7
- Format:
- Supplied as a liquid in PBS, 1% BSA, 0.09% sodium azide.
- Weitere Details:
- Tenascin is a large hexameric extracellular matrix molecule with oncofetal properties. During embryonic development the protein is expressed in many parenchymatous organs, where it appears to have a regulating role in epithelial differentiation. In most mature tissues the expression is restricted to the papillary dermis, but reappears in tissue regeneration and repair and in neoplasia. In basal cell carcinoma two forms (Mr 210,000 and 300,000) of tenascin can be found, in contrast to normal skin and fibroblasts, where one form predominantly exists (Mr 300,000). Tenascins were first characterized in the early 1980’s. Only recently have more elective studies been done. These studies have now attempted to reveal more specific points in carcinogenesis and pathological tissue reactions. It has been demonstrated that tenascin immunoreactivity in breast carcinoma cells could be indicative of metastasis and survival. Recent studies showed that the expression of tenascin in invasion border of early breast cancer significantly correlates with higher risk of distant metastasis. The preliminary results of these studies clearly suggest that expression of tenascin in invasion border of early breast cancer is significantly associated with proliferative activity and higher risk of local recurrence. This result implicates a wide application for tenascin antibodies in the breast pathology. Tenascin expression may suggest situations in which even small breast carcinomas may need more intensive complementary therapy. Recent studies have also shown that tenascin is significantly increased in airway basement membrane of asthmatics and rapidly decreases by inhaled steroid. This suggests that tenascin expression may be used to monitor the disease status and outcome of treatment in different types of asthma. Applications: Suitable for use in Immunofluorecence, Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilution: Immunohistochemistry: formalin-fixed and paraffin. Optimal dilution determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice