Substance P (NK, Neurokinin) (Not for Export EU)

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£704.00

SKU:: S8000-11
Reinheit:: Serum
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Substance P.
Format:: Supplied as a liquid, 0.09% sodium azide.
Weitere Details:: Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapse. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs. Applications: Suitable for use in Immunohistochemistry and RIA. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Paraffin): 1:100. Antigen retrieval with Citrate pH 6.0 is recommended RIA: 1:10,000. 80% binding detects ~5pg/ml. Optimal dilutions to be determined by the researcher. Recommended Control: Spinal Cord Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.