S6606-50V
ST2V (Suppressor of Tumorigenicity 2, ST2, ST2L, DER4, FIT-1, Homolog of Mouse Growth Stimulation-expressed, IL33R, Interleukin 1 Receptor-like 1, IL1RL1, Interleukin 1 Receptor-related Protein, Lymphocyte Antigen 84, Ly84, MGC32623, T1 Protein)
Größe
£594.00
- SKU:
- S6606-50V
- Anwendung:
- WB
- Reinheit:
- Purified by Protein G affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to aa207-238 of human ST2V. Species Sequence Homology: rat, chicken and monkey
- Format:
- Supplied as a liquid in PBS, 0.05% sodium azide.
- Weitere Details:
- ST2V is a 259aa membrane protein belonging to the interleukin 1 receptor family with two transmembrane helices, one TIR domain and three Ig-like C2-type (immunoglobulin-like) domains. ST2V is a novel variant of human ST2 which has isoforms ST2L, ST2S, ST2V and ST2LV. It is usually expressed in the human leukemic cell line UT-7 and it's sublines UT-7:GM, UT-7:EPO, and UT-7:TPO, in addition to human helper T cell line 5C10. Reports suggest that it is possibly involved in helper T-cell function. ST2V can be induced by proinflammatory stimuli and is a receptor for interleukin-33 (IL-33). IL-33 binds to and signals through ST2V and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3:ERK1 and/or MAPK1:ERK2, MAPK14, and MAPK8. The possible roles of ST2V in growth and differentiation are intriguing. It is predominantly expressed in stomach, small intestine and colon. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 3-5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Daudi and NIH 3T3 cell lysate Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice