SOCS4 (Suppressor Of Cytokine Signaling 4, SOCS-4, Suppressor of Cytokine Signaling 7, SOCS-7, SOCS7)

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£642.00

SKU:: S1040-04J
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide corresponding to C-SKVRVLRIDAPEQQ, from SOCS4, at C-terminal (NP_543143.1, NP_955453.1).
Format:: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Weitere Details:: Suppressors of cytokine signaling (SOCS) protein family includes eight members in humans: SOCS-1 through SOCS-7 and cytokine-inducible Src-homology 2 (SH2) containing protein (CIS). All members of the family have similar structure: variable length (50-380aa) and aa sequence N-terminal region, SH2 domain in the center, and homologous C-terminal 40aa long sequence that was named SOCS box. Studies have demonstrated that animals lacking normal SOCS function exhibit high cytokine activity that leads to a variety of inflammatory and autoimmune diseases and even cancer. SOCS-4 is the least studied member of the SOCS family. It is 440aa long and has 90% identical sequence in SH2 region with SOCS-5. Recent studies revealed that SOCS-4 is involved in degradation of epidermal growth factor receptor (EGFR). Specifically, SOCS-4 binds to pY1092 EGFR site. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice