S1014-49L
Smac (Second Mitochondria-derived Activator of Caspase, Smac Protein, 0610041G12Rik, DBOH, Direct IAP-binding Protein with Low pI, Diablo, Diablo Homolog (Drosophila), Diablo Homolog, Diablo Homolog Mitochondrial Precursor, DIABLO S, DIABLO-S, FLJ10537, FLJ25049, Mitochondrial Smac Protein, SMAC3, SMAC 3)
Größe
£594.00
- SKU:
- S1014-49L
- Reinheit:
- Ascites
- Lagerbedingungen:
- 4°C Do Not Freeze
- Hersteller:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant mature human Smac/DIABLO (lacks amino acids 1-55 present in Smac/DIABLO precursor)
- Klon:
- 78-1-118
- Format:
- Supplied as a liquid, 0.09% sodium azide
- Weitere Details:
- Smac/DIABLO, a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms (2,3). Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:500. Detects a band at ~25kD representing Smac/DIABLO. For better results, IP prior to Western Blot is recommended. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
- Versandbedingungen:
- Blue Ice