S1013-88J1
SIRT 5 (Sirtuin 5, Sirtuin-5, Sirtuin Type 5, NAD-dependent Deacetylase Sirtuin 5, Silent Mating Type Information Regulation 2 (S. cerevisiae) Homolog 5, Sir2-like 5, SIR2L5)
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£745.00
- SKU:
- S1013-88J1
- Reinheit:
- Purified by Protein G affinity chromatography.
- Lagerbedingungen:
- 4°C (-20°C Glycerol)
- Hersteller:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Ovalbumin-conjugated synthetic peptide corresponding to N-terminal aa1-50 of human silent information regulator 2 homolog (Sirt5)
- Klon:
- 5i85
- Format:
- Supplied as a liquid in PBS, pH 7.2, 40% glycerol.
- Weitere Details:
- SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Versandbedingungen:
- Blue Ice