S1013-87
SIRP alpha (SIRPA, Tyrosine-Protein Phosphatase Non-receptor Type Substrate 1, SHP Substrate 1, SHPS-1, Brain Ig-like Molecule with Tyrosine-based Activation Motifs, Bit, CD172a, CD172 Antigen-like Family Member A)
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£655.00
- SKU:
- S1013-87
- Reinheit:
- Purified by immunoaffinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to 17aa, KPEPSFSEYASVQVPRK, at the C-terminal of human SIRPa1. Species sequence homology: bovine, based on 88% homology with the immunogen sequence.
- Format:
- Supplied as a liquid in PBS containing 0.02% sodium azide.
- Weitere Details:
- Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPalpha, SHPS-1, MyD-1, BIT and p84. SIRPalpha is a new gene family containing at least fifteen members. SIRPalpha is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2. SIRPalpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes. Applications: Sutiable for use in ELISA, Immunocytochemistry and Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 0.5-1ug/ml. Predicted molecular weight: 75-110kD. Immunocytochemistry: 1ug/ml Optimal dilutions to be determined by researcher. Positive Control: Whole cell lysate from THP-1 cells. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice