Secretogranin-5 (Secretogranin 5, SCG5, Secretogranin V, SgV, 7B2, Neuroendocrine Protein 7B2, P7B2, Pituitary Polypeptide, Secretory Granule Endocrine Protein I, SGNE1) (Not for Export EU)

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£564.00

SKU:: S0626-05C
Reinheit:: Serum
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to aa126-159 from porcine Secretogranin-5.
Format:: Supplied as a lyophilized powder. Reconstitute with 50ul sterile ddH2O.
Weitere Details:: Secretogranin-5 is an acidic protein of 186aa and has an expression that seems to be restricted to neurons and endocrine cells. In the brain, it is most abundant in the supraoptic and paraventricular nuclei of the hypothalamus. It acts in neuroendocrine cells as a specific chaperone for proprotein convertase-2 (PC2) which is an important endoprotease involved in the processing of neuroendocrine precursors. It binds to inactive proPC2 in the ER and facilitates its movement toward the secretory pathway where proPC2 is proteolytically matured and activated. It also plays a role in regulating pituitary hormone secretion. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence. Other applications not tested. Recommended Dilutions: Western Blot: 1:500 detected Secretogranin-5 in rat brain tissue. Immunofluorescence: 1:200 Immunohistochemistry (PAP or ABC): 1:500 Optimal dilutions to be determined by the researcher. Amino Acid Sequence: Glu-Phe-Gly-Leu-Gln-Leu-His-Gln-His-Leu-Phe-Asp-Pro-Glu-His -Asp-Tyr-Pro-Gly-Lys-Trp-Asn-Lys-Lys-Leu-Leu-Tyr-Glu-Lys-Met -Lys-Gly-Gly-Gln Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Versandbedingungen:: Blue Ice