S0097-71
SARM (SAM and ARM-containing Protein)
Größe
£767.00
- SKU:
- S0097-71
- Anwendung:
- IP
- Reinheit:
- Purified from concentrated hybridoma tissue culture supernatant.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to aa93-292 from human SARM.
- Klon:
- 6D754 (Sarmy-1)
- Format:
- Supplied as a liquid in PBS, 0.02% sodium azide, 10% glycerol.
- Weitere Details:
- In mammals, TIR domain adapters, including Myd88, TIRAP, TICAM-1 (also called TRIF), and TRAM, act in Toll-like receptor (TLR) signaling pathway. The last member of this family called SARM (sterile and armadillo motifs) is highly conserved but has no known function in any organism. SARM is the only mammalian TIR-domain adapter proteins conserved in C. elegans, suggesting that SARM is the most ancient member of this class of signaling proteins. Overexpression of SARM fails to activate either NF-kB- or IRF-3-dependent reporter gene expression, two transcription factors that are sensitive to TLR signaling, suggesting that SARM is functionally distinct from other mammalian TIR domain-containing proteins. Applications: Suitable for use in Immunoprecipitation. Not suitable for Western Blot. Other applications not tested. Recommended Dilutions: Immunoprecipitation: 1:200 Optimal dilutions to be determined by the researcher. Storage and Stability: For long-term storage, aliquot and store at -20°C. Aliquots are stable for 12 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Versandbedingungen:
- Blue Ice