S0097-50

Saracatinib, Free Base (N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine, AZD-0530)

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£194.00

SKU:: S0097-50
Molekulargewicht:: 542.03
Reinheit:: HPLC: ~99%. TLC: ~99%
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
CAS Number:: 379231-04-6
Format:: Supplied as a white to off-white crystalline powder.
Weitere Details:: Saracatinib an orally available Src kinase inhibitor. Saracatinib inhibits c-Src and Abl enzymes at low nanomolar concentrations. Saracatinib blocked the tumor growth of a c-Src-transfected 3T3-fibroblast xenograft in vivo and increased significantly the survival of animals in a highly aggressive model of human pancreatic cancer. Solubility: Soluble in DMSO at 200mg/ml; soluble in ethanol at 200mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 20-100uM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 6 months after receipt.