RAPSN (43kD Receptor-associated Protein of the Synapse, RAPsyn, 43kD Postsynaptic Protein, Acetylcholine Receptor-associated 43kD Protein, RING Finger Protein 205, RNF205)

Größe

£642.00

SKU:: R1139-50E
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide corresponding to YQSNQTEKALQVWTK-C, from human RAPSN, at N-terminal (NP_005046.2, NP_116034.2).
Format:: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Weitere Details:: Rapsyn (receptor-associated protein of the synapse) is a peripheral membrane protein that has a close association to acetylcholine receptors (AChRs). Studies have shown that mice with a mutated rapsyn gene were unable to form AChR clusters, resulting in birth from respiratory failure death soon after. Other mutations affecting the activity of rapsyn can lead to the formation of the neuromuscular disease myasthenia gravis. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:128,000 Western Blot: 0.3-1ug/ml, observed in human skeletal muscle lysates on ~38kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.