RAP80 (Receptor Associated Protein 80, Receptor-associated Protein 80, Nuclear Zinc Finger Protein RAP80, Retinoid X Receptor-interacting Protein, Retinoid X Receptor-interacting Protein 110, RIP110, Rxrip110, Ubiquitin Interaction Motif-containing 1, Ubiquitin Interaction Motif-containing Protein 1, UIMC1)

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£642.00

SKU:: R1115-40E
Reinheit:: Purified by peptide affinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide corresponding to C-TRRQKEAKTKSDSG, from the internal region of human RAP80 (NP_057374.3).
Format:: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Weitere Details:: Receptor Associated Protein 80 (RAP80) is a 79.8kD nuclear acidic protein. RAP80 acts as a transcriptional repressor, inhibiting the interaction of NR6A1 with the co-repressor NCOR1. Studies have demonstrated that RAP80 is recruited by CCDC98 to BRCA1 allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Along with CCDC98, RAP80 is required for DNA damage resistance, G2-M checkpoint control and DNA repair. RAP80 is highly expressed by germ cells of the testis and is also expressed in the ovary, thymus and heart. Research has shown the existence of at least four isoforms of RAP80. Applications: Suitable for use in ELISA. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:32,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.