P3352-32C

Peroxiredoxin 6 (PRDX6, PRDX-6, Prdx6-rs3, 1-Cys Peroxiredoxin, 1-Cys PRX, 1-Cys-PRX, 1-CysPrx, 9430088D19Rik, Acidic Calcium-independent Phospholipase A2, aiPLA2, Antioxidant Protein 2, AOP2, AOP2-rs3, Brp-12, CP-3, EC=1.11.1.15, GPx, KIAA0106, Liver 2D Page Spot 40, Ltw4, Lvtw-4, MGC46173, mKIAA0106, Non-selenium Glutathione Peroxidase, NSGPx, ORF06, p29, PHGPx, PRX, Red Blood Cells Page Spot 12, Thiol-specific Antioxidant Protein) (Not for Export EU)

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£735.00

SKU:: P3352-32C
Reinheit:: Serum
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Rat recombinant Peroxiredoxin-6. Homologous in human and mouse peroxiredoxin-6.
Format:: Supplied as a lyophilized powder. Reconstitute with 100ul sterile dH2O.
Weitere Details:: FUNCTION: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. SUBUNIT: Homotetramer. SUBCELLULAR LOCATION: Cytoplasm. Lysosome. Also found in lung secretory organelles. MISCELLANEOUS: The active site is the redox-active Cys-47 oxidized to Cys-SOH. Cys-SOH may rapidly react with a Cys-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin. MISCELLANEOUS: Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress. SIMILARITY: Belongs to the ahpC/TSA family. Rehydrin subfamily. Applications: Suitable for use in ELISA, Western Blot and Imunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:4000 Western Blot: 1:1000-1:4000 Immunohistochemistry 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Versandbedingungen:: Blue Ice