P3292-05B

PGRP-S (Peptidoglycan Recognition Protein-S, MGC126894, MGC126896, Peptidoglycan Recognition Protein 1, PGLYRP1, Peptidoglycan Recognition Protein, PGLYRP, PGRP, PGRP-PEN, TAG7, TNF Superfamily Member 3 (LTB)-like, TNF Superfamily Member 3-like, TNFSF3L)

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£512.00

SKU:: P3292-05B
Reinheit:: Purified by Protein G affinity chromatography
Lagerbedingungen:: 4°C Do Not Freeze
Hersteller:: United States Biological
Host:: Mouse
Immunogen:: KLH-conjugated synthetic peptide corresponding to aa165-180 (YVLKGHRDVQRTLSPG) of human PGRP-S
Klon:: 188C424
Format:: Supplied as a liquid in PBS, 0.05% sodium azide.
Weitere Details:: The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-Ib) define a new family of human pattern recognition molecules. PGRP-S is present in neutrophils and inhibits growth of Gram-positive bacteria and, therefore, may function as a neutrophil antibacterial protein. However, PGRP-S may have another, as yet unidentified function because in humans it is expressed in the bone marrow 50-100 times higher than in neutrophils. Applications: Suitable for use in, Flow Cytometry, Immunohistochemistry, Western Blot and Immunofluorescence/Immunocytochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 1:10-1:1000 Immunofluorescence (IC): 1:10-1:2000 Immunohistochemistry: 1:10-1:2000 Western Blot: 2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse spleen Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Versandbedingungen:: Blue Ice