p53 Binding Protein 1 (53BP1, 53-BP1, FLJ41424, MGC138366, p202, p53BP1, Tumor Protein 53 Binding Protein 1, Tumor Protein p53 Binding Protein 1, TP53BP1, Tumor Suppressor p53 Binding Protein 1)

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£665.00

SKU:: P1001-25P
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to a region between aa1925-1972 at the C-terminal of human tumor protein p53 binding protein 1. (NP_005648.1)
Format:: Supplied as a liquid in Tris-citrate/phosphate, pH 7.5, 0.09% sodium azide.
Weitere Details:: P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunofluorescence (IC): 1:50-1:1000 Western Blot: 1:2000-1:10,000. Immunohistochemistry: Paraffin sections Optimal dilutions to be determined by the researcher. Positive Control: U205, 293T, and MO59K cell lysates (human) and MEF lysates (mouse) Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.