N6000-28
NTH1 (E. coli Endonuclease III Homologue)
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£594.00
- SKU:
- N6000-28
- Reinheit:
- Purified by affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- A peptide derived from the human NTH1.
- Format:
- Supplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
- Weitere Details:
- Oxygen radicals damage chromosonal DNA causing cell death and inducing mutations. Although a major focus of oxidatively damaged DNA has centered on the repair of 8-oxo-G, a number of other damaged DNA sites are created by free-radical attack on DNA. The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites. A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. Research indicates NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA. Positive control: K562 cell extracts , Hela cell extracts.
- Versandbedingungen:
- Blue Ice