N6000-26A

NTAL (Non-T Cell Activation Linker, HSPC046, Linker for Activation of B cells, LAB, Lat2, Membrane Associated Adapter Molecule, Williams Beuren Syndrome Chromosome Region 5, WBSCR5, WSCR5, WBSCR15)

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£614.00

SKU:: N6000-26A
Reinheit:: Purified by Protein A affinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to aa91-243 of human NTAL at the cytoplasmic domain.
Klon:: NAP-07
Format:: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Weitere Details:: NTAL (non-T cell activation linker), also known as LAB (linker for activation of B cells), is a 30kD double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function. Applications: Suitable for use in Immunoprecipitation, Immunohistochemistry, Immunocytochemistry and Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1-2ug/ml Immunohistochemistry: paraffin Flow Cytometry (Intracellular staining): 1-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.