N5378-07B
NP-5 (Alpha Defensin 5, Defensin 5, DEF5, Defensin alpha 5, Defensin alpha 5 Paneth Cell-specific, Defensin alpha 5 Preproprotein, DEFA5, HD5, HD-5, HNP5, HNP-5, MGC129728)
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£626.00
- SKU:
- N5378-07B
- Reinheit:
- Purified by Protein G affinity chromatography
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Full-length proHD5 protein The propeptide is the full-length protein. In the mature form it is cleaved at residue 63 (alanine). Cellular Localization: Secreted.
- Klon:
- 9A8
- Format:
- Supplied as a liquid in Tris-glycine, 150mM sodium chloride, 0.05% sodium azide.
- Weitere Details:
- Human neutrophil alpha-defensins (also designated HNPs) are small, cationic, cysteine-rich antimicrobial proteins that play important roles in innate immunity against infectious microbes such as bacteria, fungi and enveloped viruses. Alpha-defensins are synthesized as inactive precursors and are activated by proteolytic cleavage by MMP-7. In the mature form, NP-5 is cleaved at residue 63 (alanine). Paneth cells in small intestinal crypts secrete the alpha-defensins, which are also termed cryptidins in mice. Alpha-defensins 5 and 6 probably contribute to innate defense of the GI mucosal surface by protecting against microbial invasion in states of intestinal inflammation. Applications: Suitable for use in Immunofluorescence, ELISA, Western Blot. Dot Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (FFPE): 5-10ug/ml Immunohistochemistry (Frozen): 5-10ug/ml Western Blot: 1:1000 Immunofluorescence (IC): 1:200-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice