M4692-75
Msx2 (Hox8, Homeobox Protein MSX-2, Hox-8)
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£672.00
- SKU:
- M4692-75
- Reinheit:
- Purified by Protein A affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein fragment corresponding to aa1-77 from the N-terminal region of human Msx2.
- Klon:
- 4E158 (2E12)
- Format:
- Supplied as a liquid in PBS, pH 7.2, 50% glycerol.
- Weitere Details:
- Msx2, also known as HOX-8, is a homeobox containing transcription factor which is a member of the MSH family of homeobox proteins. Homeobox genes (HOX genes), encode DNA binding proteins that recognize specific sequences and modulate transcriptional activity (1). Msx-2 is believed to play a role in regulating bone development, particularly in sutures of cranial bone (5). Msx-2 is also expressed in sites of skin appendage formation and it has been proposed that Msx-2 is involved in the growth of skin and skin appendages (6). Msx2 mRNA is found expressed at higher levels in immature tumors, including a yolk sac tumor, seminoma, and chroiocarcinoma, and also in various tumors of epithelial origin (2). Msx2 gene expression is frequently activated in carcinoma-derived cell lines. The gene is inactive in NIH3T3 cells but is transcriptionally activated after transformation by v-Ki-ras suggesting that the Msx2 may play a role in cell transformation (3). Msx2 defects are a cause of craniosynostosis type 2 (CRS2), a disease that is characterized by premature fusion of calvarial sutures that leads to abnormal skull shape (4). Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot (ECL): 1ug/ml Immunohistochemistry: 1-10ug/ml Optimal dilutions to be determined by researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Versandbedingungen:
- Blue Ice