MOP3 (Members of PAS Superfamily, BMAL1, Brain And Muscle ARNT-like 1, JAP3, PAS3, CYCLE)

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£767.00

SKU:: M4590-12
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: 4°C (-20°C Glycerol)
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: A 15-aa peptide sequence within the C-terminus of Human MOP3 was synthesized coupled to KLH
Format:: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 0.1%BSA and 40% glycerol.
Weitere Details:: Circadian rhythm is one of the most fascinating and complex biological phenomenon's. The circadian clock controls biological activities on daily light-dark cycles in species from cyanobacteria to humans. The circadian clock has three major components: A photoactive pigment (chromophore) for sensing light and transmitting light signals, the circadian clock that oscillates every ~24-hrs, and the genes controlled by the circadian clock to bring about the physiological and behavioral changes. Several genes (Drosophila Clock Per, Tim; mammalian Per1, Per2, Per3, MOP3 and MOP4, and BMAL1) have been linked to rhythmicity or circadian behavior of living organisms. However, very little is known about the mammalian photosensory molecules.Basic-helix-loop-helix-PAS orphan protein, MOP3 (Members Of PAS Superfamily; also known as BMAL1/JAP3/PAS3; 626 aa) is a general dimerization partner for several PAS superfamily of transcription regulators. MOP3 interacts with MOP4 (also known as NPAS2; 626 aa), Clock, HIF1a, and HIF2a. MOP4 is a brain specific homolog of Clock. Applications: Suitable for use in ELISA. Western Blot, though not tested, may potentially be used as an application. Other applications not tested. Recommended Dilution: Western Blot: 1-10ug/ml using ECL. ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well. Optimal dilutions to be determined by the researcher. Control Peptide: M4591-02B Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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