M2352-02C
MAP Kinase p38 alpha (Mitogen-activated Protein Kinase p38 alpha, MAPK p38 alpha, Cytokine Suppressive Anti-inflammatory Drug-binding Protein, CSAID-binding Protein, CSBP, CSBP1, CSBP2, CSPB1, EXIP, MAP Kinase MXI2, MAX-interacting Protein 2, Mitogen-activated Protein Kinase 14, MAP Kinase 14, MAPK 14, MAPK14, MXI2, p38ALPHA, PRKM14, PRKM15, RK, Stress-activated Protein Kinase 2a, SAPK2a)
Größe
£626.00
- SKU:
- M2352-02C
- Anwendung:
- WB
- Reinheit:
- Purified
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to human p38a MAPK.
- Klon:
- 13G9(7D6)
- Format:
- Supplied as a liquid in sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, <0.02% sodium azide, 50% glycerol.
- Weitere Details:
- p38 MAP kinase (MAPK), also called RK (1) or CSBP (2), is the mammalian ortholog of the yeast HOG kinase that participates in a signaling cascade controlling cellular responses to cytokines and stress (1-4). Four isoforms of p38 MAP kinase, p38 alpha, beta, gamma (also known as ERK6 or SAPK3) and delta (also known as SAPK4) have been identified. Similar to the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), UV light and growth factors (1-5). MKK3, MKK6 and SEK activate p38 MAP kinase by phosphorylation at Thr180 and Tyr182. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase 2 (3) and to phosphorylate the transcription factors ATF-2 (5), Max (6) and MEF2 (5-8). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice