L2020-76D

LRRTM3 (Leucine-rich Repeat Transmembrane Neuronal Protein 3, UNQ803/PRO1693)

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£812.00

SKU:: L2020-76D
Anwendung:: IHC-Fr
Reinheit:: Purified by Protein A affinity chromatography from hybridoma culture supernatant.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to Glu31-Lys419 from human LRRTM3, expressed in NSO cells.
Klon:: 11n125
Format:: Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
Weitere Details:: Human LRRTM3 (leucine-rich repeat transmembrane neuronal 3) is a 63kD (predicted) type I transmembrane glycoprotein that is one of four LRRTM family members within the LRR protein superfamily (1). The LRRTM3 cDNA encodes 581aa, including a 389aa extracellular region that shares 98% aa identity with mouse and rat LRRTM3. Isoform 2 lacks cytoplasmic aa514-581. LRRTMs in mouse show distinct expression patterns during formation of the central nervous system (CNS) and expression persists in adult brain. LRRTM3 promotes processing of amyloid precursor protein by BACE1, and may be mutated in late-onset Alzheimer’s disease. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 8-25ug/ml detected in immersion fixed paraffin-embedded sections of human brain with Alzheimer's disease. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Versandbedingungen:: Blue Ice