KLF4 (Krueppel-like Factor 4, Epithelial Zinc Finger Protein EZF, Gut-enriched Krueppel-like Factor, EZF, GKLF)

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£642.00

SKU:: K1891-41H
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide corresponding to AVSDALLPSFST-C, from human KLF4, at N-terminal (NP_004226.2).
Format:: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Weitere Details:: KLF4 is a protein belonging to the krueppel C2H2-type zinc-finger protein family, consisting of three C2H2-type zinc fingers. It functions as a cell cycle checkpoint protein, induces squamous epithelial dysplasia and maintains the integrity of the G2/M checkpoint following DNA damage. KLF4 prevents centrosome amplification following gamma radiation-induced DNA damage and plays a role in the differentiation of epithelial cells and in the development of the skeleton and kidney. Its inactivation leads to bladder carcinogenesis and gastric carcinogenesis. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:64,000 Western Blot: 0.1-0.3ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.