Kv7.3 (KCNQ3, Potassium Voltage-gated Channel, KQT-like Subfamily, Member 3, BFNC2, EBN2, KQT-like 3, Potassium Channel Subunit alpha KvLQT3, Potassium Voltage-gated Channel Subfamily KQT Member 3, Voltage-gated Potassium Channel Subunit Kv7.3)

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£448.00

SKU:: K0138-04
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptidecorresponding to C-SDSVWTPSNKPI from the C-Terminus of human KCNQ3. Species sequence homology: mouse, rat, porcine.
Format:: Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Weitere Details:: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:16000 Western Blot: 0.3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human Brain (Cerebral Cortex, Amygdala, Hippocampus) lysates Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for 12 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Versandbedingungen:: Blue Ice