Jumonji Domain-Containing Protein 2C (JMJD2C, Lysine-Specific Demethylase 4C, JMJD2, Gene Amplified in Squamous Cell Carcinoma 1, GASC1, JmjC Domain-Containing Histone Demethylation Protein 3C, JHDM3C, KDM4C)

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£812.00

SKU:: J7876-47
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: 4°C Do not freeze
Hersteller:: United States Biological
Host:: Rabbit
Format:: Supplied as a liquid in Tris-citrate/phosphate buffer, pH 7.5, 0.09% sodium azide.
Weitere Details:: Jumonji Domain Containing 2C is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Applications: Suitable for use in Western Blot, Chromatin Immunoprecipitation and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 1:2000-1:10,000 Immunoprecipitation: 1:2-5ug/mg lysate Chromatin Immunoprecipitation: 1:10-1:500 Optimal dilutions to be determined by the researcher. Positive Control: HeLa whole cell extract Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.